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Erik A Bey Selected Research

quinone (benzoquinone)

1/2020Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer.
10/2013Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers.
6/2012An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis.
1/2011Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy.
10/2010Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation.
5/2010Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy.
1/2009Intratumoral delivery of beta-lapachone via polymer implants for prostate cancer therapy.
10/2007Beta-lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells.
7/2007Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
7/2007An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.
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Erik A Bey Research Topics

Disease

24Neoplasms (Cancer)
10/2020 - 01/2005
5Necrosis
12/2016 - 10/2010
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2020 - 07/2007
4Lung Neoplasms (Lung Cancer)
01/2019 - 07/2007
4Pancreatic Neoplasms (Pancreatic Cancer)
06/2013 - 01/2005
3Prostatic Neoplasms (Prostate Cancer)
10/2010 - 04/2005
1Triple Negative Breast Neoplasms
07/2014
1Breast Neoplasms (Breast Cancer)
10/2013
1Hemolytic Anemia
01/2011
1Ataxia Telangiectasia (Louis Bar Syndrome)
07/2007
1Genomic Instability
07/2007
1Carcinogenesis
09/2006

Drug/Important Bio-Agent (IBA)

18beta-lapachoneIBA
12/2016 - 01/2005
13NAD (NADH)IBA
01/2020 - 01/2005
13quinone (benzoquinone)IBA
01/2020 - 01/2005
9Oxidoreductases (Dehydrogenase)IBA
01/2020 - 01/2005
7EnzymesIBA
10/2013 - 07/2007
5Adenosine Triphosphate (ATP)IBA
01/2019 - 10/2010
5Pharmaceutical PreparationsIBA
12/2016 - 07/2007
4DNA (Deoxyribonucleic Acid)IBA
01/2014 - 07/2007
4Reactive Oxygen Species (Oxygen Radicals)IBA
10/2013 - 10/2010
3Poly (ADP-Ribose) Polymerase-1IBA
10/2013 - 09/2006
3MicellesIBA
01/2013 - 10/2007
3Antineoplastic Agents (Antineoplastics)IBA
01/2009 - 07/2007
2CatalaseIBA
01/2019 - 10/2013
2Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
12/2016 - 01/2014
2Poly(ADP-ribose) Polymerase InhibitorsIBA
12/2016 - 01/2014
2deoxynyboquinoneIBA
07/2014 - 06/2012
2Proteins (Proteins, Gene)FDA Link
01/2014 - 12/2006
2PolymersIBA
01/2009 - 10/2007
1Untranslated RNA (Noncoding RNA)IBA
10/2020
1Biological ProductsIBA
10/2020
1Long Noncoding RNAIBA
10/2020
11,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
01/2019
1Radiation-Sensitizing AgentsIBA
07/2014
1TankyrasesIBA
01/2014
1Telomerase (Telomerase Reverse Transcriptase)IBA
01/2014
1NucleotidesIBA
10/2013
1Oxygen (Dioxygen)IBA
06/2013
1Hemoglobins (Hemoglobin)IBA
06/2013
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
01/2013
1IronIBA
01/2013
1IonsIBA
01/2013
1Small Interfering RNA (siRNA)IBA
01/2011
1CalpainIBA
10/2010
1TOR Serine-Threonine KinasesIBA
10/2009
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
10/2009
1ORALIT (ORS)IBA
02/2009
1cyclic (arginyl- glycyl- aspartyl- phenylalanyl- lysyl)IBA
02/2009
12-Hydroxypropyl-beta-cyclodextrinIBA
01/2009
1poly(lactide) (polylactic acid)IBA
10/2007
1NADP (NADPH)IBA
10/2007
1monomethoxypolyethyleneglycol- polylactide block copolymerIBA
10/2007
1Ethylene Glycol (Monoethylene Glycol)IBA
10/2007
1DNA-Activated Protein KinaseIBA
07/2007
1Phosphotransferases (Kinase)IBA
07/2007
1Phosphatidylinositols (Phosphatidylinositol)IBA
07/2007
1Serine (L-Serine)FDA Link
07/2007
1Threonine (L-Threonine)FDA Link
07/2007
1lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA
07/2007
1PoisonsIBA
07/2007
1Type I DNA Topoisomerases (Topoisomerase I)IBA
07/2007
1CaspasesIBA
07/2007
1Transforming Growth Factor beta1 (TGF beta 1)IBA
12/2006
1NaphthoquinonesIBA
12/2006
1Alkylating AgentsIBA
12/2006
1ClusterinIBA
12/2006
1A-Form DNA (A-DNA)IBA
09/2006
1mu-calpainIBA
04/2005
1ProdrugsIBA
04/2005
11,2-naphthoquinoneIBA
01/2005
1CyclodextrinsIBA
01/2005

Therapy/Procedure

11Therapeutics
01/2019 - 04/2005
3Drug Therapy (Chemotherapy)
05/2010 - 01/2005
2Radiotherapy
01/2005 - 01/2005
1Blood Transfusion (Blood Transfusions)
06/2013
1Intraperitoneal Injections
01/2005